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Oxynorm 5 mg for Pain Management Oxynorm 5 mg is a powerful medication often prescribed to alleviate moderate to severe pain that can’t be controlled with lighter analgesics. Oxynorm contains oxycodone hydrochloride, an opioid that changes how the brain interprets pain signals. Patients dealing with pain after surgery or with chronic illnesses like cancer are often given Oxynorm for relief. We’ll explore what Oxynorm 5 mg does, when it’s appropriate